CYANOCOBALAMIN (VITAMIN B12)
Cov Duab thiab Cov Khoom
Cov khoom no yog xim liab dawb los yog hmoov crystalline, tsis muaj ntxhiab, tsis qab thiab muaj zog ua rau noo noo. Yaj me ntsis hauv dej lossis ethanol, tsis yaj hauv chloroform lossis ether. Tiv taus kub, tab sis nws yuav tsis zoo thaum raug rau cov tshuaj oxidizing lossis txo cov tshuaj, cov ntsev hlau hnyav thiab cov kua qaub muaj zog thiab cov alkali muaj zog.
Cov Qauv Tshuaj
Vitamin B12 yog ib qho equioctaphedral compound uas muaj cobalt ions. Nws lub hauv paus qauv yog ib lub nplhaib corrin tiaj tus uas muaj plaub lub pyrroles txuas nrog. Cov molecules ntawm vitamin B12 yog kwv yees li ntawm 3 qhov chaw: ib lub nplhaib gourin chylated los ntawm plaub N atoms thiab central cobalt ions; 5,6-dimethylbenzimidazole txuas nrog N-7 atoms thiab cobalt ions ua vitamin B 12 molecules ntawm cov ligands qis. Tsis tas li ntawd, DMBI kuj txuas nrog aminopropanol los ntawm phosphate pawg, thiab aminopropanol yog covalently txuas nrog propionic acid sab saw ntawm pyrrole D; adenosyl pawg lossis methyl pawg Nws txuas nrog cobalt ions los tsim cov ligand sab saud ntawm vitamin B12 molecules.
Kev Ua Haujlwm ntawm Lub Cev
Qhov tsis txaus vitamin B12 tuaj yeem ua rau mob hlwb peripheral neuritis. Cov tsos mob thaum ntxov ntawm qhov tsis txaus vitamin B12 hauv cov menyuam yaus yog kev xav tsis zoo, kev hais lus qeeb, kev teb qeeb, thiab thaum kawg ua rau muaj ntshav tsis txaus. Txhawb kev loj hlob thiab kev loj hlob ntawm cov qe ntshav liab. Methylpropandiyl coenzyme A hloov mus ua succinoyl coenzyme A thiab koom nrog hauv lub voj voog tricarboxylic acid, uas succinyl coenzyme A cuam tshuam nrog kev tsim cov heme. Vitamin B12 kuj koom nrog kev tsim cov deoxynucleic acid (DNA), kev ua haujlwm ntawm cov rog, carbohydrates thiab protein, thiab ua rau cov nucleic acids thiab protein ntau ntxiv.
